Guduchi, Tinospora cordifolia (Willd.) Miers. is one among the most important medicinal plants of India and has been used in Ayurvedic preparations for the treatment of various ailments. The accepted botanical source of Guduchi throughout India is Tinospora cordifolia (Willd.) Miers., but, this species of plant is dioecious, where male and female flowers are borne on separate plants. However, this factor is not given proper consideration while collecting the plant material for medicinal purposes. The present study was undertaken to evaluate ghrita per se, Guduchi ghrita prepared by using male and female plants of Tinospora cordifolia for adaptogenic activity in forced swimming stress model in albino rats to know whether the gender factor of the plant material used for preparation of ghrita formulation will influence the pharmacological activity or not. Parameters like rectal temperature, ulcer index, weight of adrenal glands, biochemical parameters in stomach tissue homogenate like total protein nucleic acids, catalase activity, lipid peroxidation, total glutathione content, glutathione peroxidase activity, super oxide dismutase activity, adrenal ascorbic acid content, different haematological parameters and histopathological changes in stomach were studied. In this study, Guduchi Ghrita formulations exhibited significant adaptogenic and anti-ulcer activities.
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